Drug Repurposing Analysis Report - asthma
📊 Analysis Overview
14
Total Candidate Drugs
0.841
Average Predicted Score
0.874
Highest Predicted Score
0
Known Drugs
🏆 Top 14 Candidate Drugs
| ID | Name | pvalue | rank | Score | # Shared Genes | Paths | Existing | # Overlap Pathways | Overlap Pathways | Key Genes | # Key Genes | Degree | # Shared Genes | Shared Gene Names | # Shared Diseases | Shared Disease Names |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| DrugBank:DB00184 | NICOTINE | 0.00141 | 22 | 0.874 | 13 | BDNF;AVP;CD8A;MMP1;PTGS2;CRP;MMP9;MMP2;Tnf;Il6;Ptgs2;Mmp9;Sirt1 | No | 132 | AGE-RAGE signaling pathway in diabetic complications;AMPK signaling pathway;Acute myeloid leukemia;Adipocytokine signaling pathway;African trypanosomiasis;Allograft rejection;Alzheimer disease;Amoebiasis;Antigen processing and presentation;Apelin signaling pathway;Apoptosis;Arachidonic acid metabolism;Autophagy;B cell receptor signaling pathway;Bladder cancer;Breast cancer;C-type lectin receptor signaling pathway;Cellular senescence;Central carbon metabolism in cancer;Chagas disease;Chemical carcinogenesis;Chemokine signaling pathway;Chronic myeloid leukemia;Cocaine addiction;Colorectal cancer;Complement and coagulation cascades;Coronavirus disease;Cytokine-cytokine receptor interaction;Cytosolic DNA-sensing pathway;Diabetic cardiomyopathy;Endometrial cancer;Epstein-Barr virus infection;Estrogen signaling pathway;Fc epsilon RI signaling pathway;Fluid shear stress and atherosclerosis;Focal adhesion;FoxO signaling pathway;Gastric cancer;Glioma;Graft-versus-host disease;Growth hormone synthesis, secretion and action;HIF-1 signaling pathway;Hematopoietic cell lineage;Hepatitis B;Hepatitis C;Hepatocellular carcinoma;Herpes simplex virus 1 infection;Hippo signaling pathway;Human T-cell leukemia virus 1 infection;Human cytomegalovirus infection;Human immunodeficiency virus 1 infection;Human papillomavirus infection;Hypertrophic cardiomyopathy;IL-17 signaling pathway;Inflammatory bowel disease;Inflammatory mediator regulation of TRP channels;Influenza A;Insulin resistance;JAK-STAT signaling pathway;Kaposi sarcoma-associated herpesvirus infection;Legionellosis;Leishmaniasis;Leukocyte transendothelial migration;Lipid and atherosclerosis;Longevity regulating pathway;MAPK signaling pathway;Malaria;Measles;Melanoma;MicroRNAs in cancer;Mitophagy;NF-kappa B signaling pathway;NOD-like receptor signaling pathway;Natural killer cell mediated cytotoxicity;Necroptosis;Neuroactive ligand-receptor interaction;Neurotrophin signaling pathway;Neutrophil extracellular trap formation;Non-alcoholic fatty liver disease;Non-small cell lung cancer;Osteoclast differentiation;Ovarian steroidogenesis;Oxytocin signaling pathway;PD-L1 expression and PD-1 checkpoint pathway in cancer;PI3K-Akt signaling pathway;Pancreatic cancer;Pathogenic Escherichia coli infection;Pathways in cancer;Pathways of neurodegeneration;Pertussis;Phospholipase D signaling pathway;Platelet activation;Prion disease;Prolactin signaling pathway;Prostate cancer;Proteoglycans in cancer;RIG-I-like receptor signaling pathway;Rap1 signaling pathway;Ras signaling pathway;Regulation of actin cytoskeleton;Regulation of lipolysis in adipocytes;Relaxin signaling pathway;Renal cell carcinoma;Renin secretion;Rheumatoid arthritis;Salmonella infection;Serotonergic synapse;Shigellosis;Signaling pathways regulating pluripotency of stem cells;Small cell lung cancer;Sphingolipid signaling pathway;T cell receptor signaling pathway;TGF-beta signaling pathway;TNF signaling pathway;Th1 and Th2 cell differentiation;Th17 cell differentiation;Thyroid cancer;Thyroid hormone signaling pathway;Toll-like receptor signaling pathway;Toxoplasmosis;Transcriptional misregulation in cancer;Tuberculosis;Type I diabetes mellitus;Type II diabetes mellitus;VEGF signaling pathway;Viral carcinogenesis;Viral protein interaction with cytokine and cytokine receptor;Yersinia infection;cAMP signaling pathway;cGMP-PKG signaling pathway;mTOR signaling pathway;p53 signaling pathway | BDNF | 1 | 1784 | 14 | COX2|MMP9|Il6|Sirt1|ELANE|CD8A|Mmp9|BDNF|MMP1|Tnf|CRP|AVP|PTGS2|MMP2|Ptgs2 | 6 | osteoarthritis|Sepsis|respiratory failure|skin disorder|ulcerative colitis|ischemic disease |
| DrugBank:DB00368 | NOREPINEPHRINE | 0.00167 | 26 | 0.869 | 12 | BDNF;AGT;AVP;CX3CL1;PTGS2;CRP;KCNMB2;Tnf;Il6;Nos2;Lep;Hif1a | No | 88 | AGE-RAGE signaling pathway in diabetic complications;AMPK signaling pathway;Adipocytokine signaling pathway;African trypanosomiasis;Alzheimer disease;Amoebiasis;Arginine and proline metabolism;Arginine biosynthesis;Bladder cancer;C-type lectin receptor signaling pathway;Chagas disease;Chemical carcinogenesis;Cocaine addiction;Coronavirus disease;Cytokine-cytokine receptor interaction;Cytosolic DNA-sensing pathway;Estrogen signaling pathway;Fc epsilon RI signaling pathway;Fluid shear stress and atherosclerosis;FoxO signaling pathway;Graft-versus-host disease;Growth hormone synthesis, secretion and action;HIF-1 signaling pathway;Hematopoietic cell lineage;Hepatitis B;Human T-cell leukemia virus 1 infection;Human cytomegalovirus infection;Hypertrophic cardiomyopathy;IL-17 signaling pathway;Inflammatory bowel disease;Inflammatory mediator regulation of TRP channels;Influenza A;Insulin resistance;JAK-STAT signaling pathway;Kaposi sarcoma-associated herpesvirus infection;Legionellosis;Leishmaniasis;Lipid and atherosclerosis;Long-term depression;Longevity regulating pathway;MAPK signaling pathway;Malaria;Measles;NF-kappa B signaling pathway;NOD-like receptor signaling pathway;Necroptosis;Neuroactive ligand-receptor interaction;Non-alcoholic fatty liver disease;Osteoclast differentiation;Ovarian steroidogenesis;Oxytocin signaling pathway;PI3K-Akt signaling pathway;Pathogenic Escherichia coli infection;Pathways in cancer;Pathways of neurodegeneration;Pertussis;Phospholipase D signaling pathway;Prion disease;Prolactin signaling pathway;Prostate cancer;Proteoglycans in cancer;RIG-I-like receptor signaling pathway;Rap1 signaling pathway;Ras signaling pathway;Regulation of lipolysis in adipocytes;Relaxin signaling pathway;Renal cell carcinoma;Renin secretion;Renin-angiotensin system;Rheumatoid arthritis;Salmonella infection;Serotonergic synapse;Shigellosis;T cell receptor signaling pathway;TNF signaling pathway;Th17 cell differentiation;Toll-like receptor signaling pathway;Transcriptional misregulation in cancer;Tuberculosis;Type I diabetes mellitus;Type II diabetes mellitus;VEGF signaling pathway;Vascular smooth muscle contraction;Viral protein interaction with cytokine and cytokine receptor;Yersinia infection;cAMP signaling pathway;cGMP-PKG signaling pathway;mTOR signaling pathway | AGT | 1 | 1291 | 12 | CX3CL1|Il6|F2|Hif1a|Nos2|Tnf|AGT|CRP|AVP|PTGS2|Lep|BDNF|KCNMB2 | 9 | Fibrosis|Coronary Disease|atherosclerosis|heart disorder|cardiovascular disorder|Sepsis|myocardial infarction|diabetes mellitus|rheumatoid arthritis |
| MESH:D011453 | Prostaglandins | 0.00270 | 42 | 0.851 | 17 | HSPA4;AGT;AVP;IL1A;VIP;PTGS2;IL10;PCLAF;COX1;Il6;Tgfb1;Ptgs2;Nos2;COX2;Il1b;Nfkb1;Ptgds | No | 119 | AGE-RAGE signaling pathway in diabetic complications;Acute myeloid leukemia;Adipocytokine signaling pathway;African trypanosomiasis;Allograft rejection;Alzheimer disease;Amoebiasis;Antigen processing and presentation;Apoptosis;Arachidonic acid metabolism;Arginine and proline metabolism;Asthma;Autoimmune thyroid disease;B cell receptor signaling pathway;Bladder cancer;Breast cancer;C-type lectin receptor signaling pathway;Cellular senescence;Chagas disease;Chemical carcinogenesis;Chronic myeloid leukemia;Colorectal cancer;Coronavirus disease;Cytokine-cytokine receptor interaction;Cytosolic DNA-sensing pathway;Diabetic cardiomyopathy;Endometrial cancer;Epstein-Barr virus infection;Estrogen signaling pathway;Fc epsilon RI signaling pathway;Fluid shear stress and atherosclerosis;Focal adhesion;FoxO signaling pathway;Gastric cancer;Glioma;Graft-versus-host disease;Growth hormone synthesis, secretion and action;HIF-1 signaling pathway;Hematopoietic cell lineage;Hepatitis B;Hepatitis C;Hepatocellular carcinoma;Herpes simplex virus 1 infection;Human T-cell leukemia virus 1 infection;Human cytomegalovirus infection;Human papillomavirus infection;Hypertrophic cardiomyopathy;IL-17 signaling pathway;Inflammatory bowel disease;Inflammatory mediator regulation of TRP channels;Influenza A;Insulin resistance;Intestinal immune network for IgA production;JAK-STAT signaling pathway;Kaposi sarcoma-associated herpesvirus infection;Legionellosis;Leishmaniasis;Lipid and atherosclerosis;Long-term depression;Longevity regulating pathway;MAPK signaling pathway;Malaria;Measles;Melanoma;MicroRNAs in cancer;NF-kappa B signaling pathway;NOD-like receptor signaling pathway;Necroptosis;Neuroactive ligand-receptor interaction;Non-alcoholic fatty liver disease;Non-small cell lung cancer;Osteoclast differentiation;Ovarian steroidogenesis;Oxytocin signaling pathway;PD-L1 expression and PD-1 checkpoint pathway in cancer;PI3K-Akt signaling pathway;Pancreatic cancer;Pathogenic Escherichia coli infection;Pathways in cancer;Pathways of neurodegeneration;Pertussis;Phospholipase D signaling pathway;Platelet activation;Prion disease;Prolactin signaling pathway;Prostate cancer;Proteoglycans in cancer;RIG-I-like receptor signaling pathway;Rap1 signaling pathway;Ras signaling pathway;Regulation of actin cytoskeleton;Regulation of lipolysis in adipocytes;Relaxin signaling pathway;Renal cell carcinoma;Renin secretion;Renin-angiotensin system;Rheumatoid arthritis;Salmonella infection;Serotonergic synapse;Small cell lung cancer;Sphingolipid signaling pathway;T cell receptor signaling pathway;TGF-beta signaling pathway;TNF signaling pathway;Th1 and Th2 cell differentiation;Th17 cell differentiation;Toll-like receptor signaling pathway;Toxoplasmosis;Transcriptional misregulation in cancer;Tuberculosis;Type I diabetes mellitus;Type II diabetes mellitus;VEGF signaling pathway;Vascular smooth muscle contraction;Viral protein interaction with cytokine and cytokine receptor;Yersinia infection;cAMP signaling pathway;cGMP-PKG signaling pathway;mTOR signaling pathway | PTGS2 | 1 | 212 | 17 | COX2|Il6|IL10|Tgfb1|COX1|VIP|F2|AVP|PCLAF|Nos2|Il1b|AGT|Ptgds|HSPA4|PTGS2|IL1A|Nfkb1|Ptgs2 | 12 | seasonal allergic rhinitis|Fibrosis|endometriosis|lung disorder|osteoarthritis|heart disorder|cardiovascular disorder|hypertensive disorder|status asthmaticus|diabetes mellitus|ischemic disease|rheumatoid arthritis |
| DrugBank:DB04630 | ALDOSTERONE | 0.00309 | 48 | 0.846 | 13 | AGT;AVP;NR3C1;IL1A;VIP;CRP;MMP9;ADIPOQ;TIMP1;Il6;Nr3c1;Ccn2;Timp1 | No | 105 | AGE-RAGE signaling pathway in diabetic complications;AMPK signaling pathway;Adipocytokine signaling pathway;African trypanosomiasis;Alzheimer disease;Amoebiasis;Apelin signaling pathway;Bladder cancer;Breast cancer;C-type lectin receptor signaling pathway;Cellular senescence;Central carbon metabolism in cancer;Chagas disease;Chemical carcinogenesis;Chronic myeloid leukemia;Colorectal cancer;Coronavirus disease;Cytokine-cytokine receptor interaction;Diabetic cardiomyopathy;Endometrial cancer;Epstein-Barr virus infection;Estrogen signaling pathway;Fc epsilon RI signaling pathway;Fluid shear stress and atherosclerosis;Focal adhesion;FoxO signaling pathway;Gastric cancer;Glioma;Graft-versus-host disease;Growth hormone synthesis, secretion and action;HIF-1 signaling pathway;Hematopoietic cell lineage;Hepatitis B;Hepatitis C;Hepatocellular carcinoma;Hippo signaling pathway;Human T-cell leukemia virus 1 infection;Human cytomegalovirus infection;Human immunodeficiency virus 1 infection;Human papillomavirus infection;Hypertrophic cardiomyopathy;IL-17 signaling pathway;Inflammatory bowel disease;Inflammatory mediator regulation of TRP channels;Influenza A;Insulin resistance;Intestinal immune network for IgA production;JAK-STAT signaling pathway;Kaposi sarcoma-associated herpesvirus infection;Leishmaniasis;Leukocyte transendothelial migration;Lipid and atherosclerosis;Long-term depression;Longevity regulating pathway;MAPK signaling pathway;Malaria;Melanoma;MicroRNAs in cancer;NOD-like receptor signaling pathway;Natural killer cell mediated cytotoxicity;Necroptosis;Neuroactive ligand-receptor interaction;Neurotrophin signaling pathway;Non-alcoholic fatty liver disease;Non-small cell lung cancer;Osteoclast differentiation;Ovarian steroidogenesis;Oxytocin signaling pathway;PD-L1 expression and PD-1 checkpoint pathway in cancer;PI3K-Akt signaling pathway;Pancreatic cancer;Pathways in cancer;Pathways of neurodegeneration;Pertussis;Phospholipase D signaling pathway;Prolactin signaling pathway;Prostate cancer;Proteoglycans in cancer;Rap1 signaling pathway;Ras signaling pathway;Regulation of actin cytoskeleton;Regulation of lipolysis in adipocytes;Relaxin signaling pathway;Renal cell carcinoma;Renin secretion;Renin-angiotensin system;Rheumatoid arthritis;Serotonergic synapse;Sphingolipid signaling pathway;TGF-beta signaling pathway;TNF signaling pathway;Th17 cell differentiation;Thyroid cancer;Toll-like receptor signaling pathway;Transcriptional misregulation in cancer;Tuberculosis;Type I diabetes mellitus;Type II diabetes mellitus;VEGF signaling pathway;Vascular smooth muscle contraction;Yersinia infection;cAMP signaling pathway;cGMP-PKG signaling pathway;mTOR signaling pathway;p53 signaling pathway | AGT | 1 | 1455 | 14 | MMP9|Il6|Nr3c1|Ccn2|NR3C1|VIP|ADIPOQ|AGT|Timp1|CRP|AVP|TIMP1|IL1A|FPR1 | 6 | Fibrosis|myocardial infarction|hypertensive disorder|kidney disorder|chronic kidney disease|diabetes mellitus |
| DrugBank:DB01050 | IBUPROFEN | 0.00315 | 49 | 0.846 | 5 | IL1A;PTGS2;Tnf;COX1;COX2 | No | 84 | AGE-RAGE signaling pathway in diabetic complications;Adipocytokine signaling pathway;African trypanosomiasis;Allograft rejection;Alzheimer disease;Amoebiasis;Antigen processing and presentation;Apoptosis;Arachidonic acid metabolism;C-type lectin receptor signaling pathway;Cellular senescence;Chagas disease;Chemical carcinogenesis;Chronic myeloid leukemia;Colorectal cancer;Complement and coagulation cascades;Coronavirus disease;Cytokine-cytokine receptor interaction;Cytosolic DNA-sensing pathway;Diabetic cardiomyopathy;Epstein-Barr virus infection;Fluid shear stress and atherosclerosis;Gastric cancer;Graft-versus-host disease;HIF-1 signaling pathway;Hematopoietic cell lineage;Hepatitis B;Hepatitis C;Herpes simplex virus 1 infection;Human T-cell leukemia virus 1 infection;Human cytomegalovirus infection;Human immunodeficiency virus 1 infection;Human papillomavirus infection;Hypertrophic cardiomyopathy;IL-17 signaling pathway;Inflammatory bowel disease;Inflammatory mediator regulation of TRP channels;Influenza A;Insulin resistance;JAK-STAT signaling pathway;Kaposi sarcoma-associated herpesvirus infection;Legionellosis;Leishmaniasis;Lipid and atherosclerosis;MAPK signaling pathway;Malaria;Measles;MicroRNAs in cancer;NF-kappa B signaling pathway;NOD-like receptor signaling pathway;Necroptosis;Non-alcoholic fatty liver disease;Osteoclast differentiation;Ovarian steroidogenesis;PD-L1 expression and PD-1 checkpoint pathway in cancer;PI3K-Akt signaling pathway;Pancreatic cancer;Pathogenic Escherichia coli infection;Pathways in cancer;Pathways of neurodegeneration;Pertussis;Prion disease;Prostate cancer;RIG-I-like receptor signaling pathway;Regulation of lipolysis in adipocytes;Rheumatoid arthritis;Salmonella infection;Serotonergic synapse;Shigellosis;Small cell lung cancer;Sphingolipid signaling pathway;T cell receptor signaling pathway;TNF signaling pathway;Th1 and Th2 cell differentiation;Th17 cell differentiation;Toll-like receptor signaling pathway;Toxoplasmosis;Transcriptional misregulation in cancer;Tuberculosis;Type I diabetes mellitus;Viral protein interaction with cytokine and cytokine receptor;Yersinia infection;cAMP signaling pathway;p53 signaling pathway | PTGS2 | 1 | 2370 | 5 | COX2|COX1|Tnf|PTGS2|IL1A | 11 | urticaria|Fibrosis|Inflammation|lung disorder|osteoarthritis|systemic lupus erythematosus|Sepsis|arthritic joint disease|skin disorder|ischemic disease|rheumatoid arthritis |
| DrugBank:DB00328 | INDOMETHACIN | 0.00328 | 51 | 0.845 | 25 | AGT;AVP;IL1A;MPO;SELL;MMP1;PTGS2;IL1RN;MMP9;MMP2;PLAU;PCLAF;TIMP1;Tnf;COX1;Il6;Tgfb1;Ptgs2;Nos2;COX2;Il1b;Nfkb1;Ptgds;Alox5;Serpinb1-ps1 | No | 121 | AGE-RAGE signaling pathway in diabetic complications;Acute myeloid leukemia;Adipocytokine signaling pathway;African trypanosomiasis;Allograft rejection;Alzheimer disease;Amoebiasis;Apelin signaling pathway;Apoptosis;Arachidonic acid metabolism;Bladder cancer;Breast cancer;C-type lectin receptor signaling pathway;Cell adhesion molecules;Cellular senescence;Chagas disease;Chemical carcinogenesis;Chemokine signaling pathway;Chronic myeloid leukemia;Cocaine addiction;Colorectal cancer;Complement and coagulation cascades;Coronavirus disease;Cytokine-cytokine receptor interaction;Cytosolic DNA-sensing pathway;Diabetic cardiomyopathy;Endometrial cancer;Epstein-Barr virus infection;Estrogen signaling pathway;Fluid shear stress and atherosclerosis;Focal adhesion;FoxO signaling pathway;Gastric cancer;Glioma;Graft-versus-host disease;HIF-1 signaling pathway;Hematopoietic cell lineage;Hepatitis B;Hepatitis C;Hepatocellular carcinoma;Hippo signaling pathway;Human T-cell leukemia virus 1 infection;Human cytomegalovirus infection;Human papillomavirus infection;Hypertrophic cardiomyopathy;IL-17 signaling pathway;Inflammatory bowel disease;Inflammatory mediator regulation of TRP channels;Influenza A;Insulin resistance;Intestinal immune network for IgA production;JAK-STAT signaling pathway;Kaposi sarcoma-associated herpesvirus infection;Legionellosis;Leishmaniasis;Leukocyte transendothelial migration;Lipid and atherosclerosis;Longevity regulating pathway;MAPK signaling pathway;Malaria;Measles;Melanoma;MicroRNAs in cancer;NF-kappa B signaling pathway;NOD-like receptor signaling pathway;Natural killer cell mediated cytotoxicity;Necroptosis;Neuroactive ligand-receptor interaction;Neutrophil extracellular trap formation;Non-alcoholic fatty liver disease;Non-small cell lung cancer;Osteoclast differentiation;Ovarian steroidogenesis;Oxytocin signaling pathway;PD-L1 expression and PD-1 checkpoint pathway in cancer;PI3K-Akt signaling pathway;Pancreatic cancer;Pathogenic Escherichia coli infection;Pathways in cancer;Pathways of neurodegeneration;Pertussis;Phagosome;Phospholipase D signaling pathway;Prion disease;Prolactin signaling pathway;Prostate cancer;Proteoglycans in cancer;RIG-I-like receptor signaling pathway;Rap1 signaling pathway;Ras signaling pathway;Regulation of actin cytoskeleton;Regulation of lipolysis in adipocytes;Relaxin signaling pathway;Renal cell carcinoma;Renin secretion;Renin-angiotensin system;Rheumatoid arthritis;Salmonella infection;Serotonergic synapse;Shigellosis;Small cell lung cancer;Sphingolipid signaling pathway;Staphylococcus aureus infection;Systemic lupus erythematosus;T cell receptor signaling pathway;TGF-beta signaling pathway;TNF signaling pathway;Th1 and Th2 cell differentiation;Th17 cell differentiation;Thyroid cancer;Toll-like receptor signaling pathway;Toxoplasmosis;Transcriptional misregulation in cancer;Tuberculosis;Type I diabetes mellitus;Type II diabetes mellitus;Vascular smooth muscle contraction;Viral protein interaction with cytokine and cytokine receptor;Yersinia infection;cAMP signaling pathway;cGMP-PKG signaling pathway | PTGS2 | 1 | 2705 | 27 | COX2|F2|MMP1|PCLAF|Nos2|Ptgds|PTGS2|MMP2|IL1A|BDNF|Alox5|Serpinb1-ps1|COX1|AGT|AVP|TIMP1|Nfkb1|Il6|IL1RN|FCGR3A|PLAU|MMP9|SELL|MPO|Tnf|Il1b|Tgfb1|Ptgs2 | 15 | Eosinophilia|lung disorder|pustulosis palmaris et plantaris|osteoarthritis|systemic lupus erythematosus|respiratory failure|hypertensive disorder|Airway Obstruction|arthritic joint disease|kidney disorder|status asthmaticus|diabetes mellitus|skin disorder|drug allergy|rheumatoid arthritis |
| DrugBank:DB00806 | PENTOXIFYLLINE | 0.00412 | 64 | 0.836 | 3 | FPR1;CRP;Tnf | No | 80 | AGE-RAGE signaling pathway in diabetic complications;Adipocytokine signaling pathway;African trypanosomiasis;Allograft rejection;Amoebiasis;Antigen processing and presentation;Apoptosis;C-type lectin receptor signaling pathway;Chagas disease;Colorectal cancer;Complement and coagulation cascades;Coronavirus disease;Cytokine-cytokine receptor interaction;Diabetic cardiomyopathy;Epstein-Barr virus infection;Fc epsilon RI signaling pathway;Fluid shear stress and atherosclerosis;Focal adhesion;Graft-versus-host disease;HIF-1 signaling pathway;Hematopoietic cell lineage;Hepatitis B;Human T-cell leukemia virus 1 infection;Human cytomegalovirus infection;Human immunodeficiency virus 1 infection;Human papillomavirus infection;Hypertrophic cardiomyopathy;IL-17 signaling pathway;Inflammatory bowel disease;Influenza A;JAK-STAT signaling pathway;Kaposi sarcoma-associated herpesvirus infection;Legionellosis;Leishmaniasis;Leukocyte transendothelial migration;Lipid and atherosclerosis;MAPK signaling pathway;Malaria;Measles;Mitophagy;NF-kappa B signaling pathway;NOD-like receptor signaling pathway;Natural killer cell mediated cytotoxicity;Necroptosis;Neuroactive ligand-receptor interaction;Neurotrophin signaling pathway;Neutrophil extracellular trap formation;Non-alcoholic fatty liver disease;Osteoclast differentiation;PI3K-Akt signaling pathway;Pancreatic cancer;Pathogenic Escherichia coli infection;Pathways in cancer;Pertussis;Proteoglycans in cancer;RIG-I-like receptor signaling pathway;Rap1 signaling pathway;Regulation of lipolysis in adipocytes;Relaxin signaling pathway;Renal cell carcinoma;Renin secretion;Rheumatoid arthritis;Salmonella infection;Shigellosis;Sphingolipid signaling pathway;Staphylococcus aureus infection;T cell receptor signaling pathway;TGF-beta signaling pathway;TNF signaling pathway;Th1 and Th2 cell differentiation;Th17 cell differentiation;Toll-like receptor signaling pathway;Toxoplasmosis;Tuberculosis;Type I diabetes mellitus;Type II diabetes mellitus;Viral myocarditis;Yersinia infection;cAMP signaling pathway;cGMP-PKG signaling pathway | CRP | 1 | 1885 | 3 | Tnf|CRP|FPR1 | 17 | Fibrosis|endometriosis|pulmonary fibrosis|breast neoplasm|lung disorder|pustulosis palmaris et plantaris|diabetes mellitus|atherosclerosis|systemic sclerosis|Sepsis|vascular disorder|myocardial infarction|arthritic joint disease|kidney disorder|lung neoplasm|ischemic disease|rheumatoid arthritis |
| DrugBank:DB06151 | ACETYLCYSTEINE | 0.00431 | 67 | 0.835 | 9 | AGT;FPR1;IL1A;PTGS2;CRP;MMP9;Tnf;Ptgs2;Nfkb1 | No | 129 | AGE-RAGE signaling pathway in diabetic complications;AMPK signaling pathway;Acute myeloid leukemia;Adipocytokine signaling pathway;African trypanosomiasis;Allograft rejection;Alzheimer disease;Amoebiasis;Antigen processing and presentation;Apoptosis;Asthma;Autophagy;B cell receptor signaling pathway;Bladder cancer;Breast cancer;C-type lectin receptor signaling pathway;Cellular senescence;Central carbon metabolism in cancer;Chagas disease;Chemical carcinogenesis;Chemokine signaling pathway;Chronic myeloid leukemia;Cocaine addiction;Colorectal cancer;Coronavirus disease;Cytokine-cytokine receptor interaction;Cytosolic DNA-sensing pathway;Diabetic cardiomyopathy;Endometrial cancer;Epstein-Barr virus infection;Estrogen signaling pathway;Fc epsilon RI signaling pathway;Fluid shear stress and atherosclerosis;Focal adhesion;FoxO signaling pathway;Gastric cancer;Glioma;Graft-versus-host disease;Growth hormone synthesis, secretion and action;HIF-1 signaling pathway;Hematopoietic cell lineage;Hepatitis B;Hepatitis C;Hepatocellular carcinoma;Herpes simplex virus 1 infection;Human T-cell leukemia virus 1 infection;Human cytomegalovirus infection;Human immunodeficiency virus 1 infection;Human papillomavirus infection;Hypertrophic cardiomyopathy;IL-17 signaling pathway;Inflammatory bowel disease;Inflammatory mediator regulation of TRP channels;Influenza A;Insulin resistance;Intestinal immune network for IgA production;JAK-STAT signaling pathway;Kaposi sarcoma-associated herpesvirus infection;Legionellosis;Leishmaniasis;Leukocyte transendothelial migration;Lipid and atherosclerosis;Long-term depression;Longevity regulating pathway;MAPK signaling pathway;Malaria;Measles;Melanoma;MicroRNAs in cancer;Mitophagy;NF-kappa B signaling pathway;NOD-like receptor signaling pathway;Natural killer cell mediated cytotoxicity;Necroptosis;Neuroactive ligand-receptor interaction;Neurotrophin signaling pathway;Neutrophil extracellular trap formation;Non-alcoholic fatty liver disease;Non-small cell lung cancer;Osteoclast differentiation;Ovarian steroidogenesis;Oxytocin signaling pathway;PD-L1 expression and PD-1 checkpoint pathway in cancer;PI3K-Akt signaling pathway;Pancreatic cancer;Pathogenic Escherichia coli infection;Pathways in cancer;Pathways of neurodegeneration;Pertussis;Phospholipase D signaling pathway;Platelet activation;Prion disease;Prolactin signaling pathway;Prostate cancer;Proteoglycans in cancer;RIG-I-like receptor signaling pathway;Rap1 signaling pathway;Ras signaling pathway;Regulation of lipolysis in adipocytes;Relaxin signaling pathway;Renal cell carcinoma;Rheumatoid arthritis;Salmonella infection;Serotonergic synapse;Shigellosis;Signaling pathways regulating pluripotency of stem cells;Small cell lung cancer;Sphingolipid signaling pathway;Systemic lupus erythematosus;T cell receptor signaling pathway;TNF signaling pathway;Th1 and Th2 cell differentiation;Th17 cell differentiation;Thyroid cancer;Thyroid hormone signaling pathway;Toll-like receptor signaling pathway;Toxoplasmosis;Transcriptional misregulation in cancer;Tuberculosis;Type I diabetes mellitus;Type II diabetes mellitus;VEGF signaling pathway;Viral carcinogenesis;Viral myocarditis;Viral protein interaction with cytokine and cytokine receptor;Yersinia infection;cAMP signaling pathway;mTOR signaling pathway;p53 signaling pathway | MMP9 | 1 | 310 | 10 | COX2|MMP9|Ptgs2|IGF1R|Tnf|AGT|CRP|PTGS2|Nfkb1|IL1A|FPR1 | 10 | pulmonary fibrosis|lung disorder|pneumonia|systemic sclerosis|myocardial infarction|chronic kidney disease|chronic obstructive pulmonary disease|brain disorder|lung neoplasm|systemic lupus erythematosus |
| DrugBank:DB00813 | FENTANYL | 0.00482 | 75 | 0.833 | 1 | AVP | No | 45 | AGE-RAGE signaling pathway in diabetic complications;Acute myeloid leukemia;Amoebiasis;Cell adhesion molecules;Cellular senescence;Chagas disease;Chemical carcinogenesis;Complement and coagulation cascades;Coronavirus disease;Cytokine-cytokine receptor interaction;Cytosolic DNA-sensing pathway;Fc gamma R-mediated phagocytosis;HIF-1 signaling pathway;Hematopoietic cell lineage;Hepatitis B;Hypertrophic cardiomyopathy;IL-17 signaling pathway;Inflammatory bowel disease;Influenza A;JAK-STAT signaling pathway;Kaposi sarcoma-associated herpesvirus infection;Legionellosis;Leishmaniasis;Malaria;Natural killer cell mediated cytotoxicity;Neuroactive ligand-receptor interaction;Neutrophil extracellular trap formation;Non-alcoholic fatty liver disease;Osteoclast differentiation;Pathways in cancer;Pertussis;Phagosome;Phospholipase D signaling pathway;RIG-I-like receptor signaling pathway;Rheumatoid arthritis;Staphylococcus aureus infection;Systemic lupus erythematosus;TNF signaling pathway;Th17 cell differentiation;Toll-like receptor signaling pathway;Transcriptional misregulation in cancer;Tuberculosis;Vascular smooth muscle contraction;Viral protein interaction with cytokine and cytokine receptor;Yersinia infection | ITGAM | 1 | 2795 | 4 | ITGAM|FCGR3A|MPO|AVP | 9 | Inflammation|breast neoplasm|osteoarthritis|heart disorder|myocardial infarction|hypertensive disorder|kidney disorder|lung neoplasm|rheumatoid arthritis |
| DrugBank:DB03128 | ACETYLCHOLINE | 0.00495 | 77 | 0.832 | 11 | BDNF;AGT;AVP;NOS1;MYH14;MBP;KCNMB2;CA2;Apoe;Vip;Tac1 | No | 84 | AGE-RAGE signaling pathway in diabetic complications;African trypanosomiasis;Allograft rejection;Alzheimer disease;Amoebiasis;Apelin signaling pathway;Apoptosis;Arginine and proline metabolism;Arginine biosynthesis;Autophagy;C-type lectin receptor signaling pathway;Chagas disease;Chemical carcinogenesis;Coronavirus disease;Diabetic cardiomyopathy;Fc epsilon RI signaling pathway;Fc gamma R-mediated phagocytosis;Fluid shear stress and atherosclerosis;Graft-versus-host disease;Growth hormone synthesis, secretion and action;HIF-1 signaling pathway;Hepatitis B;Human cytomegalovirus infection;Human immunodeficiency virus 1 infection;Hypertrophic cardiomyopathy;IL-17 signaling pathway;Inflammatory bowel disease;Inflammatory mediator regulation of TRP channels;Influenza A;Insulin resistance;Legionellosis;Leishmaniasis;Lipid and atherosclerosis;Long-term depression;MAPK signaling pathway;Malaria;Measles;NF-kappa B signaling pathway;NOD-like receptor signaling pathway;Natural killer cell mediated cytotoxicity;Necroptosis;Neuroactive ligand-receptor interaction;Neurotrophin signaling pathway;Neutrophil extracellular trap formation;Non-alcoholic fatty liver disease;Osteoclast differentiation;Ovarian steroidogenesis;Oxytocin signaling pathway;PI3K-Akt signaling pathway;Pathogenic Escherichia coli infection;Pathways in cancer;Pathways of neurodegeneration;Pertussis;Phagosome;Phospholipase D signaling pathway;Platelet activation;Prion disease;Proteoglycans in cancer;Rap1 signaling pathway;Ras signaling pathway;Regulation of actin cytoskeleton;Regulation of lipolysis in adipocytes;Relaxin signaling pathway;Renin secretion;Renin-angiotensin system;Rheumatoid arthritis;Salmonella infection;Serotonergic synapse;Shigellosis;Sphingolipid signaling pathway;T cell receptor signaling pathway;TNF signaling pathway;Th17 cell differentiation;Toll-like receptor signaling pathway;Toxoplasmosis;Tuberculosis;Type I diabetes mellitus;Type II diabetes mellitus;VEGF signaling pathway;Vascular smooth muscle contraction;Yersinia infection;cAMP signaling pathway;cGMP-PKG signaling pathway;mTOR signaling pathway | AGT | 1 | 402 | 11 | MBP|Tac1|Vip|F2|MYH14|AGT|CA2|NOS1|AVP|Apoe|BDNF|KCNMB2 | 10 | heart disorder|vascular disorder|myocardial infarction|respiratory failure|hypertensive disorder|chronic obstructive pulmonary disease|diabetes mellitus|Dermatitis, Atopic|ischemic disease|rheumatoid arthritis |
| DrugBank:DB03843 | FORMALDEHYDE | 0.00514 | 80 | 0.832 | 3 | Trpv1;Serpinb1-ps1;Tac1 | No | 11 | Apoptosis;Breast cancer;Colorectal cancer;Complement and coagulation cascades;Fluid shear stress and atherosclerosis;Inflammatory mediator regulation of TRP channels;Measles;MicroRNAs in cancer;Neuroactive ligand-receptor interaction;Pathways in cancer;Pertussis | Trpv1 | 1 | 102 | 3 | Serpinb1-ps1|Trpv1|Tac1 | 3 | diabetes mellitus|Dermatitis, Atopic|allergic disease |
| DrugBank:DB00755 | TRETINOIN | 0.00547 | 85 | 0.829 | 23 | CCND1;BDNF;FOXO3;CD8A;IL1A;VIP;MMP1;NOS1;ARG1;IFNA1;MMP9;MMP2;PLAU;IGFBP3;KLF4;TIMP1;KCNMB2;TNFAIP3;Tnf;FOXP3;Il6;Tgfb1;Il23a | No | 137 | AGE-RAGE signaling pathway in diabetic complications;AMPK signaling pathway;Acute myeloid leukemia;Adipocytokine signaling pathway;African trypanosomiasis;Allograft rejection;Alzheimer disease;Amoebiasis;Antigen processing and presentation;Apelin signaling pathway;Apoptosis;Arachidonic acid metabolism;Arginine and proline metabolism;Asthma;Autoimmune thyroid disease;Autophagy;Axon guidance;B cell receptor signaling pathway;Bladder cancer;Breast cancer;C-type lectin receptor signaling pathway;Cellular senescence;Central carbon metabolism in cancer;Chagas disease;Chemical carcinogenesis;Chemokine signaling pathway;Chronic myeloid leukemia;Cocaine addiction;Colorectal cancer;Complement and coagulation cascades;Coronavirus disease;Cytokine-cytokine receptor interaction;Cytosolic DNA-sensing pathway;Diabetic cardiomyopathy;Endometrial cancer;Epstein-Barr virus infection;Estrogen signaling pathway;Fc epsilon RI signaling pathway;Fluid shear stress and atherosclerosis;Focal adhesion;FoxO signaling pathway;Gastric cancer;Glioma;Graft-versus-host disease;Growth hormone synthesis, secretion and action;HIF-1 signaling pathway;Hematopoietic cell lineage;Hepatitis B;Hepatitis C;Hepatocellular carcinoma;Herpes simplex virus 1 infection;Hippo signaling pathway;Human T-cell leukemia virus 1 infection;Human cytomegalovirus infection;Human immunodeficiency virus 1 infection;Human papillomavirus infection;Hypertrophic cardiomyopathy;IL-17 signaling pathway;Inflammatory bowel disease;Inflammatory mediator regulation of TRP channels;Influenza A;Insulin resistance;Intestinal immune network for IgA production;JAK-STAT signaling pathway;Kaposi sarcoma-associated herpesvirus infection;Legionellosis;Leishmaniasis;Leukocyte transendothelial migration;Lipid and atherosclerosis;Long-term depression;Longevity regulating pathway;MAPK signaling pathway;Malaria;Measles;Melanoma;MicroRNAs in cancer;Mitophagy;NF-kappa B signaling pathway;NOD-like receptor signaling pathway;Natural killer cell mediated cytotoxicity;Necroptosis;Neurotrophin signaling pathway;Neutrophil extracellular trap formation;Non-alcoholic fatty liver disease;Non-small cell lung cancer;Osteoclast differentiation;Ovarian steroidogenesis;Oxytocin signaling pathway;PD-L1 expression and PD-1 checkpoint pathway in cancer;PI3K-Akt signaling pathway;Pancreatic cancer;Pathogenic Escherichia coli infection;Pathways in cancer;Pathways of neurodegeneration;Pertussis;Phagosome;Phospholipase D signaling pathway;Prion disease;Prolactin signaling pathway;Prostate cancer;Proteoglycans in cancer;RIG-I-like receptor signaling pathway;Rap1 signaling pathway;Ras signaling pathway;Regulation of actin cytoskeleton;Relaxin signaling pathway;Renal cell carcinoma;Renin secretion;Rheumatoid arthritis;Salmonella infection;Serotonergic synapse;Shigellosis;Signaling pathways regulating pluripotency of stem cells;Small cell lung cancer;Sphingolipid signaling pathway;T cell receptor signaling pathway;TGF-beta signaling pathway;TNF signaling pathway;Th1 and Th2 cell differentiation;Th17 cell differentiation;Thyroid cancer;Thyroid hormone signaling pathway;Toll-like receptor signaling pathway;Toxoplasmosis;Transcriptional misregulation in cancer;Tuberculosis;Type I diabetes mellitus;Type II diabetes mellitus;VEGF signaling pathway;Viral carcinogenesis;Viral myocarditis;Viral protein interaction with cytokine and cytokine receptor;Yersinia infection;cAMP signaling pathway;cGMP-PKG signaling pathway;mTOR signaling pathway;p53 signaling pathway | TIMP1 | 1 | 2327 | 27 | IGFBP3|FOXP3|MMP1|MMP2|BDNF|IL1A|TNFAIP3|ARG1|FAS|TIMP1|KLF4|Il6|IFNA1|IL1R1|Il23a|NOS1|IL10|PLAU|MMP9|VIP|FOXO3|CD8A|SMAD2|Tnf|Tgfb1|CCND1|KCNMB2 | 8 | endometriosis|pulmonary emphysema|pustulosis palmaris et plantaris|atherosclerosis|hypertensive disorder|kidney disorder|brain disorder|lung neoplasm |
| DrugBank:DB12510 | OZONE | 0.00630 | 98 | 0.823 | 3 | Tnf;Il17a;Il6 | No | 57 | AGE-RAGE signaling pathway in diabetic complications;Adipocytokine signaling pathway;African trypanosomiasis;Allograft rejection;Alzheimer disease;Amoebiasis;Asthma;Bladder cancer;C-type lectin receptor signaling pathway;Cellular senescence;Chagas disease;Coronavirus disease;Cytokine-cytokine receptor interaction;Epstein-Barr virus infection;Fluid shear stress and atherosclerosis;FoxO signaling pathway;Graft-versus-host disease;HIF-1 signaling pathway;Hematopoietic cell lineage;Hepatitis B;Herpes simplex virus 1 infection;Human T-cell leukemia virus 1 infection;Human cytomegalovirus infection;Hypertrophic cardiomyopathy;IL-17 signaling pathway;Inflammatory bowel disease;Influenza A;Insulin resistance;Intestinal immune network for IgA production;Kaposi sarcoma-associated herpesvirus infection;Legionellosis;Lipid and atherosclerosis;MAPK signaling pathway;Malaria;NF-kappa B signaling pathway;NOD-like receptor signaling pathway;Non-alcoholic fatty liver disease;PI3K-Akt signaling pathway;Pathogenic Escherichia coli infection;Pathways in cancer;Pathways of neurodegeneration;Pertussis;Prion disease;RIG-I-like receptor signaling pathway;Rheumatoid arthritis;Salmonella infection;Shigellosis;Systemic lupus erythematosus;TNF signaling pathway;Th17 cell differentiation;Toll-like receptor signaling pathway;Transcriptional misregulation in cancer;Tuberculosis;Type I diabetes mellitus;Type II diabetes mellitus;Viral protein interaction with cytokine and cytokine receptor;Yersinia infection | Il6 | 1 | 95 | 3 | Tnf|Il6|Il17a | 12 | pulmonary emphysema|brain disorder|osteoarthritis|atherosclerosis|drug allergy|vascular disorder|hypertensive disorder|status asthmaticus|diabetes mellitus|Dermatitis, Atopic|ischemic disease|rheumatoid arthritis |
| MESH:D005227 | Fatty Acids | 0.00637 | 99 | 0.823 | 11 | IL1A;PTGS2;NAMPT;CRP;ADIPOQ;Tnf;CAMP;Nos2;Lep;Pparg;Adipoq | No | 76 | AGE-RAGE signaling pathway in diabetic complications;AMPK signaling pathway;Adipocytokine signaling pathway;African trypanosomiasis;Alzheimer disease;Amoebiasis;Apelin signaling pathway;Arachidonic acid metabolism;Arginine biosynthesis;C-type lectin receptor signaling pathway;Cellular senescence;Chagas disease;Chemical carcinogenesis;Complement and coagulation cascades;Coronavirus disease;Cytokine-cytokine receptor interaction;Diabetic cardiomyopathy;Fluid shear stress and atherosclerosis;FoxO signaling pathway;Graft-versus-host disease;Growth hormone synthesis, secretion and action;HIF-1 signaling pathway;Hematopoietic cell lineage;Hepatitis B;Hepatitis C;Human T-cell leukemia virus 1 infection;Human cytomegalovirus infection;Hypertrophic cardiomyopathy;IL-17 signaling pathway;Inflammatory bowel disease;Inflammatory mediator regulation of TRP channels;Influenza A;Insulin resistance;Kaposi sarcoma-associated herpesvirus infection;Legionellosis;Leishmaniasis;Lipid and atherosclerosis;Longevity regulating pathway;MAPK signaling pathway;Malaria;Measles;Melanoma;NF-kappa B signaling pathway;NOD-like receptor signaling pathway;Necroptosis;Neuroactive ligand-receptor interaction;Neutrophil extracellular trap formation;Non-alcoholic fatty liver disease;Osteoclast differentiation;Ovarian steroidogenesis;PD-L1 expression and PD-1 checkpoint pathway in cancer;PI3K-Akt signaling pathway;Pathogenic Escherichia coli infection;Pathways in cancer;Pathways of neurodegeneration;Pertussis;Prion disease;Prostate cancer;Ras signaling pathway;Regulation of lipolysis in adipocytes;Rheumatoid arthritis;Salmonella infection;Shigellosis;Small cell lung cancer;TNF signaling pathway;Toll-like receptor signaling pathway;Toxoplasmosis;Transcriptional misregulation in cancer;Tuberculosis;Type I diabetes mellitus;Type II diabetes mellitus;Viral protein interaction with cytokine and cytokine receptor;Yersinia infection;cAMP signaling pathway;mTOR signaling pathway;p53 signaling pathway | PTGS2 | 1 | 268 | 11 | COX2|Pparg|NAMPT|ADIPOQ|Adipoq|Tnf|Nos2|CRP|PTGS2|Lep|CAMP|IL1A | 15 | Fibrosis|systemic lupus erythematosus|heart disorder|myocardial infarction|respiratory failure|hypertensive disorder|arthritic joint disease|kidney disorder|chronic obstructive pulmonary disease|diabetes mellitus|ulcerative colitis|Dermatitis, Atopic|ischemic disease|colitis|rheumatoid arthritis |
Prompt for ChatGPT Deep Research
你是一个医学与药理学领域的专家，精通药物的化学成分、作用机制、分类标准及其在临床和基础研究中的应用。请基于以下药物的名称：
['NICOTINE', 'NOREPINEPHRINE', 'Prostaglandins', 'ALDOSTERONE', 'IBUPROFEN', 'INDOMETHACIN', 'PENTOXIFYLLINE', 'ACETYLCYSTEINE', 'FENTANYL', 'ACETYLCHOLINE', 'FORMALDEHYDE', 'TRETINOIN', 'OZONE', 'Fatty Acids']
为我完成如下任务，所有输出必须以**中文**呈现，并包括**结构化表格**：
#### ✅ **任务要求如下：**
1. **药物基本信息表：**
* 药物英文名
* 药物中文名
* 作用机制（详细）
* 药理分类（基于作用机制）
2. **药物对 asthma 的影响分析：**
* 每种药物提供至少**一篇权威文献（PubMed 优先）**
* 每篇文献需包含：
* 文献标题
* PMID（PubMed ID）
* 研究类型（基础/临床/综述等）
* 实验模型（如有）
* 主要发现/结论（特别强调药物对 asthma 的影响）
3. **输出格式要求：**
* 所有内容用**表格**清晰列出
* 药理分类需以机制为核心，如“酪氨酸激酶抑制剂”“抗生素类”“能量代谢调节剂”等，并给出具体分类
* 文献结论部分用**准确、简明的中文表述**
### 示例输出格式（供参考）：
#### 表1：药物基本信息与分类
| 药物英文名 | 中文名 | 作用机制说明 | 药理分类 |
| ---------- | ---------- | ------------------------------------------------------- | -------------------------- |
| Nintedanib | 尼达尼布 | 抑制VEGFR、FGFR、PDGFR等酪氨酸激酶，阻断纤维化信号通路 | 抗纤维化类酪氨酸激酶抑制剂 |
| Rifampin | 利福平 | 抑制细菌RNA聚合酶，阻断转录过程 | 抗生素（抗结核药） |
| ATP | 三磷酸腺苷 | 提供能量，参与信号传导，可作用于P2X/P2Y受体调节细胞活性 | 能量代谢与信号调节剂 |
#### 表2：药物对Scarring影响的研究文献
| 药物英文名 | 文献标题 | PMID | 研究类型 | 模型 | 主要结论 |
| ---------- | -------- | ---- | -------- | ---------------- | --------------------------------------- |
| Nintedanib | ... | ... | 临床试验 | IPF患者 | 显著减少肺部纤维化，有望用于抗瘢痕治疗 |
| Rifampin | ... | ... | 动物实验 | 大鼠皮肤创伤模型 | 可减少成纤维细胞增殖，有抗瘢痕潜力 |
| ATP | ... | ... | 细胞实验 | 人皮肤成纤维细胞 | ATP调节成纤维细胞迁移，可能影响瘢痕修复 |
Interpretation:
📈 Visualization Analysis
Drug Predicted Score Distribution
Interpretation:
Predicted Score Distribution by Knowledge Graph Inclusion
Interpretation:
Drug Similarity Heatmap
Interpretation:
Network Centrality Analysis
Interpretation:
Shared Genes and Pathways Analysis
Interpretation:
Drug Similarity Network
Interpretation:
Number of Shared Genes Between Drugs and Diseases
Interpretation:
Drug Degree vs Predicted Score
Interpretation:
Number of Overlapping Pathways Between Drugs and Diseases
Interpretation:
Number of Key Genes Distribution
Interpretation:
Ratio of Known Drugs to Predicted Drugs
Interpretation:
💡 Analysis Conclusion
Main Findings:
- The model successfully identified multiple candidate drugs, including known therapeutic drugs, verifying the effectiveness of the method.
- High-scoring drugs have higher network centrality and shared gene numbers, which is consistent with biological principles.
- Predicted drugs are similar to known drugs in multiple feature dimensions, supporting their potential therapeutic value.
Suggestions:
- Prioritize the top 10 high-scoring drugs for experimental validation.
- Focus on drugs with high shared gene numbers and overlapping pathways.
- Combine network centrality analysis to select drugs with strong regulatory capabilities.
Report Generation Time: 2025-07-04 16:37:37
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